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KMID : 0363620080290020047
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Journal of Korean Oriental Medicine
2008 Volume.29 No. 2 p.47 ~ p.59
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The Effect of the Salvia miltiorrhiza on Axon Regeneration Following Central Nervous System Injury
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Shim Ha-Na
Seong Kee-Moon
Moon Seong-Jin
Lee Seung-Hee
Yang Jae-Hoon
Song Bong-Keun
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Abstract
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Object: Reactive gliosis that is induced by central nervous system (CNS) injury is involved with up-regulation of
CD81 and GFAP. The present study was to examine the effect of the Salvia miltiorrhiza on CD81 and GFAP regulation following brain injury.
Methods: Immunoblot and ELISA methods were used to define the level of CD81 and GFAP in the astrocyte cultured from rat brain. Then immunohistochemistry was used to detect CD81 and GFAP in the injured rat brain.
Results: The following results were obtained. 1. We did western blot and ELISA to detect the protein isolated from the whole cell and they showed that CD81 and GFAP decreased. 2. We injected Salvia miltiorrhiza extract intravenously to brain-injured rats for 7 days and 30 days, and the immunohistochemistry analyses showed that CD81 and GFAP decreased significantly.
Conclusion: These results indicate that Salvia miltiorrhiza could suppress the reactive gliosis, which disturbs the
neural regeneration following CNS injury, by controlling the expression of CD81 and GFAP.
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KEYWORD
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gliosis, CD81, GFAP, salvia miltiorrhiza, CNS injury
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